DMIST was instituted under AMCP trust. It started in 2002 by offering BSC MLT course affiliated with Punjab Technical University. Later it also became study centres for Sri Venkateswara University (2005), Vinayaka Mission University (2007), National Institute of Open Schooling - NIOS (2007). Allahabad Agricultural University (2005) and Global Open University (2010). Sri Venkiteswara University was the only university approved by PSC Kerala as equivalent to open MA course of Kerala University. Doctor M Institute of Science and Technology was the only examination center of Sri Venkateswara University in Kerala. In the past, the students used to go to Tirupati in Andhra Pradesh since Venkateswara University was the only UGC university approved by the Kerala Public Service Commission and Kerala University for promotions and appointments. A large number of Kerala teachers obtained promotions and appointments by enrolling in the PG program at SV University and taking their examinations at Doctor M Institute of Science and Technology, the only examination center of S V University in Kerala.
In 2016, DMIST and DMCC moved to a permanent campus.
Sri Rajiv Prathap Rudy, Union Minister of State, inaugurated the new Trianta building on 20th February 2016.
All educational institutions under Doctor Group are managed by AMCP Trust.